Download e-book for iPad: Adaptive Design Methods in Clinical Trials, Second Edition by Shein-Chung Chow,Mark Chang

By Shein-Chung Chow,Mark Chang

ISBN-10: 1439839875

ISBN-13: 9781439839874

With new statistical and medical matters bobbing up in adaptive scientific trial layout, together with the U.S. FDA’s fresh draft counsel, a brand new version of 1 of the 1st books at the subject is required. Adaptive layout tools in medical Trials, moment Edition displays fresh advancements and regulatory positions at the use of adaptive designs in scientific trials. It unifies the huge and consistently becoming literature and examine actions on regulatory necessities, medical and functional matters, and statistical methodology.

New to the second one Edition
Along with revisions during the textual content, this version considerably updates the chapters on protocol modification and medical trial simulation to include the most recent adjustments. additionally it is 5 solely new chapters on two-stage adaptive layout, biomarker adaptive trials, aim medical trials, pattern measurement and gear estimation, and regulatory perspectives.

Following within the culture of its acclaimed predecessor, this moment variation keeps to provide an updated source for medical scientists and researchers in academia, regulatory corporations, and the pharmaceutical undefined. Written in an intuitive kind at a simple mathematical and statistical point, the publication keeps its functional method with an emphasis on techniques through a variety of examples and illustrations.

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Adaptive Design Methods in Clinical Trials, Second Edition (Chapman & Hall/CRC Biostatistics Series) by Shein-Chung Chow,Mark Chang

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